2. Metabolic Disease

Metabolic Disease

Metabolic Disease

Related Products

PDF 53.7 MB

Metabolic diseases is defined by a constellation of interconnected physiological, biochemical, clinical, and metabolic factors that directly increases the risk of cardiovascular disease, type 2 diabetes mellitus, and all cause mortality. Associated conditions include hyperuricemia, fatty liver (especially in concurrent obesity) progressing to nonalcoholic fatty liver disease, polycystic ovarian syndrome (in women), erectile dysfunction (in men), and acanthosis nigricans. Metabolic disease modeling is an essential component of biomedical research and a mandatory prerequisite for the treatment of human disease. Somatic genome editing using CRISPR/Cas9 might be used to establish novel metabolic disease models.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-W741872
    5α-Dihydrocortisol 516-41-6 98.17%
    5α-Dihydrocortisol (5α-DHF), a metabolite of Hydrocortisone (Cortisol) (HY-N0583), is a steroid hormone. 5α-Dihydrocortisol can enhance the mineralocorticoid activity of aldosterone.
    5α-Dihydrocortisol
  • HY-W746663
    Taurodeoxycholic acid-3-sulfate disodium 66874-07-5 98%
    12-Hydroxy Taurolithocholic Acid Sulfate Disodium Salt can be studied in research on lipid.
    Taurodeoxycholic acid-3-sulfate disodium
  • HY-W749966
    Octocrylene-d10 2714435-95-5 99.78%
    Octocrylene-d10 is the deuterium labeled Octocrylene. Octocrylene is an organic ultraviolet (UV) filter which absorbs mainly UVB radiation and short UVA wavelengths.
    Octocrylene-d10
  • HY-W766140
    4-Hydroxy duloxetine β-D-glucuronide sodium 98%
    4-Hydroxy duloxetine β-D-glucuronide (4-Hydroxy duloxetine glucuronide) sodium is a major metabolite of Duloxetine (HY-B0161). 4-Hydroxy duloxetine β-D-glucuronide sodium is promising for research of hepatic or renal impairment.
    4-Hydroxy duloxetine β-D-glucuronide sodium
  • HY-W773779
    GSK3-IN-9 748145-12-2 99.36%
    GSK3-IN-9 (Compound 0713) is a selective glycogen synthase kinase 3 (GSK3) inhibitor. GSK3-IN-9 Fragile X syndrome, attention deficit hyperactivity disorder (ADHD), childhood seizure, intellectual disability, diabetes, acute myeloid leukemia (AML), autism, and psychiatric disorder.
    GSK3-IN-9
  • HY-Y0289S1
    1-Dodecanol-d25 160776-83-0 98.09%
    1-Dodecanol-d25 is the deuterium labeled 1-Dodecanol. 1-Dodecanol is an endogenous metabolite.
    1-Dodecanol-d25
  • HY-Y0444S1
    D-Tyrosine-d4 944386-47-4 99.0%
    D-Tyrosine-d4 is the deuterium labeled D-Tyrosine (HY-Y0444). D-Tyrosine is the D-isomer of tyrosine. D-Tyrosine negatively regulates melanin synthesis by inhibiting tyrosinase activity. D-Tyrosine inhibits biofilm formation and trigger the self-dispersal of biofilms without suppressing bacterial growth.
    D-Tyrosine-d4
  • HY-Y0488AR
    Formic acid ammonium (Standard) 540-69-2
    Formic acid ammonium (Standard) is the analytical standard of Formic acid ammonium. This product is intended for research and analytical applications. Formic acid ammonium is the ammonium salt form of formic acid, which is an endogenous metabolite. Formic acid ammonium activates the nitric oxide/cyclic guanosine monophosphate (NO/cGMP) signaling pathway in endothelial cells and inhibits calcium ion influx in vascular smooth muscle cells, resulting in vasomotor relaxation. Formic acid ammonium inhibits cytochrome C oxidase (CcO) and disrupts the electron transport chain, leading to ATP depletion. Formic acid ammonium can be used as a feed additive, which can lower the feed pH value, inhibit the growth of microorganisms (such as Escherichia coli, Salmonella), and extend the shelf life of the feed.
    Formic acid ammonium (Standard)
  • HY-112764GL
    DMG-PEG 2000 (GMP Like) 160743-62-4
    DMG-PEG 2000 (GMP Like) is DMG-PEG 2000 (HY-112764) produced by using GMP like guidelines. GMP Like small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. DMG-PEG 2000 is used for the preparation of liposome for siRNA delivery with improved transfection efficiency in vitro. DMG-PEG 2000 is also used for the lipid nanoparticle for an oral plasmid DNA delivery approach in vivo through a facile surface modification to improve the mucus permeability and delivery efficiency of the nanoparticles.
    DMG-PEG 2000 (GMP Like)
  • HY-113365S1
    Cholestenone-13C 68165-57-1 99.0%
    Cholestenone-13C is the 13C labeled Cholestenone. Cholestenone (4-Cholesten-3-one), the intermediate oxidation product of cholesterol, is metabolized primarily in the liver. Cholestenone is highly mobile in membranes and influences cholesterol flip-flop and efflux. Cholestenone may cause long-term functional defects in cells.
    Cholestenone-13C
  • HY-113365S2
    Cholestenone-13C2 82938-09-8 99.77%
    Cholestenone-13C2 is the 13C labeled Cholestenone. Cholestenone (4-Cholesten-3-one), the intermediate oxidation product of cholesterol, is metabolized primarily in the liver. Cholestenone is highly mobile in membranes and influences cholesterol flip-flop and efflux. Cholestenone may cause long-term functional defects in cells.
    Cholestenone-13C2
  • HY-113371AS
    2-Methylcitric acid-d3 trisodium 2483831-23-6
    2-Methylcitric acid-d3 (Methylcitric acid-d3) trisodium is deuterium-labeled 2-Methylcitric acid (trisodium) (HY-113371A).
    2-Methylcitric acid-d3 trisodium
  • HY-125731S1
    Glycodeoxycholic acid-d6 2483831-98-5 99.91%
    Glycodeoxycholic acid-d6 is the deuterium labeled Glycodeoxycholic Acid. Glycodeoxycholic Acid is an endogenous metabolite.
    Glycodeoxycholic acid-d6
  • HY-125818S4
    Cytidine-5'-triphosphate-d14 dilithium 98.2%
    Cytidine-5'-triphosphate-d14 (Cytidine triphosphate-d14 dilithium; 5'-CTP-d14) dilithium is deuterium labeled Cytidine-5'-triphosphate (HY-125818). Cytidine 5′-triphosphate (Cytidine triphosphate; 5'-CTP) is a nucleoside triphosphate and serves as a building block for nucleotides and nucleic acids, lipid biosynthesis. Cytidine triphosphate synthase can catalyze the formation of cytidine 5′-triphosphate from uridine 5′-triphosphate (UTP). Cytidine 5′-triphosphate is an essential biomolecule in the de novo pyrimidine biosynthetic pathway in T. gondii.
    Cytidine-5'-triphosphate-d14 dilithium
  • HY-125818S6
    Cytidine-5'-triphosphate-15N3 dilithium
    Cytidine-5'-triphosphate-15N3 (Cytidine triphosphate-15N3 dilithium; 5'-CTP-15N3) dilithium is 15N labeled Cytidine-5'-triphosphate (HY-125818). Cytidine 5′-triphosphate (Cytidine triphosphate; 5'-CTP) is a nucleoside triphosphate and serves as a building block for nucleotides and nucleic acids, lipid biosynthesis. Cytidine triphosphate synthase can catalyze the formation of cytidine 5′-triphosphate from uridine 5′-triphosphate (UTP). Cytidine 5′-triphosphate is an essential biomolecule in the de novo pyrimidine biosynthetic pathway in T. gondii.
    Cytidine-5'-triphosphate-15N3 dilithium
  • HY-127035S3
    Tristearin-d5 55256-03-6 98.93%
    Tristearin-d5 is the deuterium labeled Tristearin (HY-127035). Tristearin is a triglyceride derived from three units of stearic acid.
    Tristearin-d5
  • HY-17504BS1
    Rosuvastatin-d6 sodium 2070009-41-3 99.9%
    Rosuvastatin-d6 sodium is deuterium labeled Rosuvastatin sodium (HY-17504B). Rosuvastatin Sodium is a competitive HMG-CoA reductase (HMGCR) inhibitor, with an IC50 of 11 nM. Rosuvastatin Sodium potently blocks hERG current with an IC50 of 195 nM. Rosuvastatin Sodium reduces the expression of the mature hERG and the interaction of heat shock protein 70 (Hsp70) with the hERG protein. Rosuvastatin Sodium effectively lowers low-density lipoprotein (LDL) cholesterol, triglycerides, and C-reactive protein levels.
    Rosuvastatin-d6 sodium
  • HY-A0132S10
    N-Acetyl-D-glucosamine-13C2,15N 478529-44-1 98%
    N-Acetyl-D-glucosamine-13C2,15N is the 13C and 15N labeled N-Acetyl-D-glucosamine. N-Acetyl-D-Glucosamine (N-Acetyl-2-amino-2-deoxy-D-glucose) is a monosaccharide derivative of gluc.
    N-Acetyl-D-glucosamine-13C2,15N
  • HY-B0141AS1
    Alpha-Estradiol-d2 81586-94-9 99.75%
    Alpha-Estradiol-d2 is the deuterium labeled Alpha-Estradiol. Alpha-Estradiol is a weak estrogen and a 5α-reductase inhibitor which is used as a topical medication in the treatment of androgenic alopecia.
    Alpha-Estradiol-d2
  • HY-B0144AS1
    Pitavastatin-d5 sodium 99.53%
    Pitavastatin-d5 (sodium) is the deuterium labeled Pitavastatin sodium. Pitavastatin (NK-104) is a potent hydroxymethylglutaryl-CoA (HMG-CoA) reductase inhibitor. Pitavastatin inhibits cholesterol synthesis from acetic acid with an IC50 of 5.8 nM in HepG2 cells. Pitavastatin is an efficient hepatocyte low-density lipoprotein-cholesterol (LDL-C) receptor inducer. Anti-cancer activity.
    Pitavastatin-d5 sodium
Cat. No. Product Name / Synonyms Application Reactivity